Free PDF Life Unfolding: How the human body creates itself, by Jamie A. Davies
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Life Unfolding: How the human body creates itself, by Jamie A. Davies
Free PDF Life Unfolding: How the human body creates itself, by Jamie A. Davies
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Where did I come from? Why do I have two arms but just one head? How is my left leg the same size as my right one? Why are the fingerprints of identical twins not identical? How did my brain learn to learn? Why must I die?
Questions like these remain biology's deepest and most ancient challenges. They force us to confront a fundamental biological problem: how can something as large and complex as a human body organize itself from the simplicity of a fertilized egg? A convergence of ideas from embryology, genetics, physics, networks, and control theory has begun to provide real answers. Based on the central principle of 'adaptive self-organization', it explains how the interactions of many cells, and of the tiny molecular machines that run them, can organize tissue structures vastly larger than themselves, correcting errors as they go along and creating new layers of complexity where there were none before.
Life Unfolding tells the story of human development from egg to adult, from this perspective, showing how our whole understanding of how we come to be has been transformed in recent years. Highlighting how embryological knowledge is being used to understand why bodies age and fail, Jamie A. Davies explores the profound and fascinating impacts of our newfound knowledge.
- Sales Rank: #704493 in Books
- Brand: imusti
- Published on: 2015-12-22
- Original language: English
- Number of items: 1
- Dimensions: 5.00" h x .70" w x 7.70" l, .0 pounds
- Binding: Paperback
- 312 pages
- Oxford University Press
Review
"From egg to adult body, Life Unfolding by Jamie Davies is a demanding but wonder-filled account of the simple interactions that create complex structures." -- Claire Ainsworth, New Scientest
"Davies offers a detailed ride through the mind-boggling number of simultaneous self-organizing activities of growth." - Publishers Weekly
About the Author
Jamie A. Davies, Professor of Experimental Anatomy, University of Edinburgh
Since 1995, Jamie A. Davies has run his own laboratory at the University of Edinburgh, with a multi-disciplinary focus on discovering how mammalian organs construct themselves and how we can use this knowledge to build new tissues and organs for those in need. He has published around 90 research papers in the field of mammalian development, published a major specialist monograph (Mechanisms of Morphogenesis, Associated Press, 2005), and edited three multi-author books in the fields of development, stem cells, and tissue engineering. He is a Fellow of the Institute of Biologists, a Fellow of the Royal Society of Medicine, and a Fellow of the HIgher Education Academy. He is also Editor-in-Chief of the journal, Organogenesis.
Most helpful customer reviews
32 of 32 people found the following review helpful.
Fascinating introduction to the way cellular dynamics can lead to biological complexity
By A. Menon
"The history of a man for the first nine months preceding his birth would probably be far more interesting than all the three score and ten years that follow it" - Samuel Taylor Coolidge. The book starts with this quote which is an excellent preamble to the contents. How a fertilized egg can transform itself through cell division into a human body with all its cell diversity is, for the vast majority of us, mind blowing. Life unfolding starts with the embryo an discusses aspects of what we know about how life develops. It can be hard to follow at times as the names of proteins and tissue regions are not easily memorized but the contents are fascinating. Life unfolding takes us through aspects of biological development looking at areas involved in conception all the way up until death. The topics are chosen to give us a sense of what people are focused on as well as how biological science is done.
The book is split into 3 core parts. The first is titled First Sketch. The author starts at the beginning and looks at the journey of a fertilized egg. It discusses the potential mechanical mechanisms that a cell employs to divide effectively. The author communicated the initial conditions well so that the complexity of processes like cell division become more understandable to us. By this I mean people don't usually think about why cell division in and of itself should be difficult ones the nucleus has divided but by describing the blindness of molecules to the geometry of the cell, the process of self organization is quickly realized to be highly non-trivial. The author discusses how the embryo moves to attach itself to the mother, how it uses mechanical principles to orient itself and start to create structure from symmetry. The author describes how the feedback mechanisms used by proteins leads to complex and differentiating behavior from uniform cell samples. The author discusses how a spherical set of cells can start to create the conditions of a body formation. One starts to get the sense of how uniformity can turn into heterogeneous behavior all through locally generated feedback mechanisms.
In the second section, Adding Details, the author moves on to discuss how the true complexity of our bodies starts to evolve. We get a sense of how stem cells start to branch depending on the feedback signals in the local area of the cells that leads to organ formation. We learn how protein concentrations affect gene activation which feedback to protein concentration and how all of these can combine to create bias in cellular movement that helps organize new tissues and organs. The author discusses the kidneys at length and how arms and legs are created can form using feedback effects. The author also discusses the differences between the chromosomes of the sexes, namely the XY and XX pairs, and how physiology is a function of certain gene representations and feedback effects due to how XY and XX behave differently and how inhibited Y chromosomes can evolve to look like women in all things but reproductive ability.
In the final core section, Refinement, the author discusses later stage life. In this section we move past the quote the book starts with and start to focus on internal evolution, the author discusses the nervous system and articulates both the incredible complexity of our neural networks as well as how feedback effects between neurons guides the way connections are formed. The author discusses the Vitruvian man and how the proportions of the body can be thrown off due to certain cellular process malfunctions. The author ends by noting how our body is constantly replenishing our cells and then dives into how the regeneration process is propagated.
Life unfolding gives the reader a sense of how symmetry is broken in cellular life. It describes aspects of the incredible complexity of our cellular life by focusing on stylized examples that are relatively simple dynamical systems that can lead to unintuitive complex outcomes. It is extremely interesting but at times overwhelming. There are a multitude of genes and proteins that the reader will be unfamiliar with and the cross referencing means the reader will have to flip back to earlier sections quite often to remind themselves of details. The fact that the author can communicate aspects of how cell complexity arises to the novice is a remarkable feat and I encourage people to read this book.
67 of 68 people found the following review helpful.
Fascinating material translated into plain English
By Steve G
The material in this book, embryology or how we develop from a fertilized egg into what we are now, is fascinating but extremely complex. However, author Jamie A. Davies did a masterful job of simplifying the material. Davies did this in several ways, including an extensive glossary, over 80 illustrations, and descriptions of experiments (not graphic so don’t worry about this). To his favour, Davies is very honest about what is known and what is conjecture. Davies used some humor and I felt that I got to know him a little. The only weak point of the book is that the complexity of the material means that some of the information may be inaccessible to a reader without some knowledge of biology. I strongly recommend this book to anyone interested in biology or science in general.
12 of 13 people found the following review helpful.
An Amazing Exploration into the Intelligence That is Fundamental in All of Life
By Richard O. Jacobs
When we think of intelligence we think of what we see and what we do and why we do; this exploration deep within the intelligence of the cells of the human body makes pales anything we think our "rational minds" produce. I had no idea the depth, creativity and importance of how cells operate. This discussion is about our body but it is representative of the process in all of life and it is amazing.
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